Hypothyroidism

Hypothyroidism (underactive thyroid) is a condition where the thyroid gland doesn't produce enough thyroid hormone. This slows metabolism and affects nearly every organ system.

About 5% of Americans ages 12+ have hypothyroidism. Hashimoto's is the most common cause.(NIH)

Key Insight

TSH alone may not tell the whole story. Antibodies reveal autoimmune thyroid disease years before TSH becomes abnormal. If you have Hashimoto's, monitor your cholesterol and B12 too.

1Primary Biomarkers

Core diagnostic markers for hypothyroidism. These are used to diagnose and monitor your condition.

TSH

Thyroid-stimulating hormone is the most sensitive marker for thyroid function. High TSH indicates hypothyroidism.

0.4-4.0 mIU/L (normal). Above 4.0 suggests underactive thyroid

Free T4

Active thyroid hormone that affects metabolism, heart rate, and body temperature.

0.8-1.8 ng/dL (normal range varies by lab)

Free T3

The most active thyroid hormone. Some patients have normal T4 but low T3 conversion.

2.3-4.2 pg/mL (varies by lab)

2Related Biomarkers

Hypothyroidism affects multiple body systems. Monitor these to catch complications early.

Thyroid Antibodies

Antibodies indicate autoimmune thyroid disease (Hashimoto's), the most common cause of hypothyroidism

Anti-TPO

Present in 90% of Hashimoto's patients. Can be elevated years before TSH changes.

Below 35 IU/mL (normal)

Anti-Thyroglobulin

Another marker for autoimmune thyroiditis.

Cholesterol Impact

Hypothyroidism raises cholesterol levels. Many patients with "high cholesterol" have undiagnosed thyroid issues.

LDL Cholesterol

Thyroid hormone affects cholesterol processing. Low thyroid = high LDL.

Total Cholesterol

Often elevated in hypothyroidism. May normalize with treatment.

Triglycerides

Can be elevated in hypothyroidism.

Anemia & Vitamins

Hashimoto's is associated with B12 deficiency and iron deficiency anemia due to autoimmune overlap

Vitamin B12

Autoimmune gastritis (pernicious anemia) is common in Hashimoto's.

Above 200 pg/mL

Ferritin

Low ferritin is common in hypothyroid patients. Iron is needed for thyroid hormone production.

Above 30 ng/mL

Hemoglobin

Hypothyroidism can cause anemia due to decreased red blood cell production.

3The Holistic View

Thyroid disease affects far more than energy levels. It impacts your heart (cholesterol, blood pressure), your blood (anemia risk), your bones, and your metabolism. If you have Hashimoto's, you're at higher risk for other autoimmune conditions.

4Connected Conditions

Understanding how hypothyroidism connects to other conditions helps you see the bigger picture.

Track in LabLi

When you select Hypothyroidism as your health focus, these categories are prioritized in your dashboard:

ThyroidLipidsCBCVitamins

Medical References

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This guide is for educational purposes only. It is not medical advice. Always consult your healthcare provider for diagnosis and treatment.